As you age, your facial skin begins to lose its elasticity and volume. As a result, your “laugh lines”, the creases that run from the sides of your nose toward the corners of your mouth, become more pronounced. Restylane Refyne injectable gel is designed to temporarily help counter this by smoothing out these wrinkles and folds and restoring a natural, soft look to your face. Restylane Refyne has been shown to maintain this effect for up to 12 months.

Restylane Refyne is injected into the facial skin through a small needle to smooth facial wrinkles and folds (laugh lines), resulting in a more youthful appearance of the skin. For most patients, the procedure only takes 15 – 30 minutes.

Patients with any of these conditions should not use Restylane Refyne:

Have severe allergies with a history of severe reactions (anaphylaxis). Use of Restylane Refyne may result in an allergic reaction.

Are allergic to the anesthetic lidocaine or to any of the proteins used to make the hyaluronic acid in Restylane Refyne (bacterial proteins). Use may result in an allergic reaction.

Restylane Refyne helps treat laugh lines – the natural facial wrinkles and folds that can occur due to aging. Restylane Refyne has not been tested to treat any other types of wrinkles.

If you have changes in your vision, signs of a stroke (including sudden difficulty speaking, numbness or weakness in your face, arms, or legs, difficulty walking, face drooping, severe 3 headache, dizziness, or confusion), white appearance of the skin, or unusual pain during or shortly after treatment, you should notify your doctor immediately.

The use of Restylane Refyne if you have skin sores, pimples, rashes, hives, cysts, or infections should be postponed until healing is complete. Use of Restylane Refyne in these instances could delay healing or make your skin problems worse.

Restylane Refyne is for adults ages 22 and older.

The safety of Restylane Refyne has not been studied in women who are pregnant or breastfeeding. The risk of using Restylane Refyne in pregnant or breastfeeding women is unknown. Talk to your doctor before using Restylane Refyne if you are pregnant, planning to become pregnant, or breastfeeding.

You may have a greater risk of developing an infection if you use Restylane Refyne while taking any medication that reduces your body’s natural defense system. These medications are called “immunosuppressants” because they stop your body’s immune system from functioning normally. Tell your doctor about any medication you are taking.

Some medication like aspirin and warfarin can thin your blood, which may increase your risk of bleeding or prolong any bleeding that occurs. These medications also increase your risk of bruising or bleeding at the injection site. Tell your doctor about any medication you are taking.

As with any injection procedure, you may have a higher risk of bruising or bleeding at the injection site if you have a bleeding disorder.

If you have any history of scarring, particularly thick and stiff scars, or any skin color (pigmentation) disorders, talk to your doctor about this before your procedure. Scarring and skin color changes can occur with hyaluronic acid fillers in general. When Restylane Refyne was studied in patients with different skin tones (pale to dark), there were no reports by patients of excessive scarring (keloids) or changes in skin color.

The use of Restylane Refyne with skin therapies such as laser treatment or chemical peels may lead to other side effects such as redness, swelling, heat and/or pain of the skin (inflammatory reaction). Tell your doctor if you have had any of these procedures.

Within the first 24 hours after treatment with Restylane Refyne, you should avoid or minimize hard (strenuous) exercise. You should also minimize exposure to extensive sun or heat, as any of these may cause temporary redness, swelling, and/or itching at the injection site. An ice pack can be applied for relief if needed.

If you have any additional questions about any topic in this section, please discuss further with your doctor.

Swelling, Bruising, Lumps/Bump Formation, Pain/Tenderness, Itching, Redness

Most patients said their side effects were mild, short-lived and did not require them to call their doctor. These patients said that their side effects disappeared within 1-2 weeks.